6 edition of Selective Estrogen Receptor Modulators (Contemporary Endocrinology) found in the catalog.
December 15, 2001
by Humana Press
Written in English
|Contributions||Andrea Manni (Editor), Michael Verderame (Editor)|
|The Physical Object|
|Number of Pages||384|
Selective estrogen-receptor modulators could also be interesting in view of their tissue-specific effect. However, all these new drugs are still in an early phase of development. • Selective estrogen receptor modulators (SERMs), also known as estrogen agonists/antagonists (ERAAs), need to interact with estrogen receptors alpha and beta (ER-α and ER-β) • The hormone-like ligand binds to the receptor through a .
Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPRDependent Mechanism Ramy Abdelhamid, Jia Luo, Lawren VandeVrede, Indraneel Kundu, Bradley Michalsen, Vladislav A. Litosh, Isaac T. Schiefer, Teshome Gherezghiher, Ping Yao, Zhihui Qin, and Gregory R. J. Thatcher *Cited by: Selective estrogen receptor modulators, called SERMs for short, block the effects of estrogen in the breast tissue. SERMs work by sitting in the estrogen receptors in breast cells. If a SERM is in the estrogen receptor, there is no room for estrogen and it can't attach to the cell. If estrogen isn't attached to a breast cell, the cell doesn't.
The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to Brand: Humana Press. ISBN: OCLC Number: Notes: "This volume is the result of the NIH Workshop on Selective Estrogen Receptor Modulators (SERMs) held April , in Bethesda, Maryland."--Page [v].
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Selective Estrogen Receptor Modulators (SERMs) | Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight : $ This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators).
The pioneering SERMs tamoxifen and raloxifene are known to have saved the lives of millions of women around the world and improved the health of millions : Hardcover. Ospemifene (os pem' i feen) is a selective estrogen receptor modulator that is used for the treatment of moderate-to-severe menopausal symptoms of dyspareunia such as vaginal atrophy, dryness, itching and irritation as well as pain on intercourse.
Selective Estrogen Receptor Modulators Research and Clinical Applications. Editors: Manni, Andrea, Verderame, Michael (Eds.) Free Preview. Buy this book eBook ,99 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free.
Their book is an up-to-date Selective Estrogen Receptor Modulators book of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue.
The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. Selective ER modulators (SERMs) are ER ligands that in some tissues act like estrogens, but block estrogen action in others thus exerting tissue‐specific effects through selective ERs.
SERMs may exhibit an agonistic or antagonistic effect depending on the context in which their activity is : Divya Lakshmanan Mangalath, Chittalakkottu Sadasivan. About this book.
Introduction. The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women.
Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain.
Abstract:Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen receptor agonists or antagonists. These drugs have been intensively studied over the past decade and have proven to be a highly versatile group for the treatment of.
Selective Estrogen Receptor Modulators (SERMs) or Estrogen Receptor Agonists/Antagonists (ERAAs) What the Clinician Should Know. The North American Menopause Society (NAMS) is pleased to present this outstanding educational content, encompassing several components, for clinicians who treat midlife women and who have questions about the benefits.
SERMS (SELECTIVE ESTROGEN RECEPTOR MODULATORS) This group have estrogenic activity on osteoporosis protection and cholestrol lowering effect with anti-oestrogenic effect on breast and no stimulatory effect on endometrium. They do not control vasomotor symptoms. Selective Estrogen Receptor Modulators by Andrea Manni,available at Book Depository with free delivery worldwide.
A compound with tissue-specific estrogen agonist and estrogen antagonist activity may be termed a selective estrogen receptor modulator (SERM).
In postmenopausal women, the SERMs tamoxifen and raloxifene preserve bone, lower circulating LDL levels, but do not treat (and may aggravate) vasomotor symptoms in some : Valerie Baker.
Tamoxifen and raloxifene reduce the risk of breast cancer in women at elevated risk of disease, but the duration of the effect is unknown. We assessed the effectiveness of selective oestrogen receptor modulators (SERMs) on breast cancer by: "Selective Estrogen Receptor Modulators: Research and Clinical Application is an indispensable resource for evaluating the use of SERM potential alternatives to estrogens.
The book synthesizes the current understanding of SERM at the levels of molecular mechanisms and clinical applications and provides a precise and balanced view of ongoing. This article discusses the clinical perspective of HRT and selective estrogen receptor modulators (SERMs) in light of the molecular and cellular mechanisms of estrogen and progesterone action on the breast.
Emphasis is placed on the potential of selective receptor modulation as the future of postmenopausal treatment. RESULTS. A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S.
Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines Agency (EMA)-approved (and FDA-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator Cited by: 5.
Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health: Progress and Promise liked it avg rating — 1 rating — published Want to Read saving 3/5(1).
Selective estrogen receptor modulators (SERMs) are molecules used to achieve selective modulation of the ERs such that it functions as an estrogen antagonist at breast level by blocking the proliferation of the cancer cells while retaining the antiosteoporotic effects of estrogen and thus functioning as an estrogen agonist at the bone level.
Selective Estrogen Receptor Modulators. Selective estrogen receptor modulators (SERMs) act as estrogen agonists or antagonists depending on the tissue.
Raloxifene, a second-generation SERM, has been shown to be an estrogen agonist in bone and liver, maintain bone density, and lower LDL cholesterol.Selective estrogen receptor modulator chemistry A key element in determining the pharmacological profile of each distinct SERM is influenced heavily by the chemical makeup of the SERM including the basic scaffold, the placement of the hydroxyl moieties, and the positioning and nature of the basic side : Jasna Markovac, Robert Marcus.Clearly written and supported by informative illustrations, it is aimed at a specialized audience and should be particularly useful to researchers and clinicians eager to advance their knowledge of these so-called 'designer estrogens'.
Selective Estrogen Receptor Modulators is an excellent collection of timely reviews.